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Semax supplied as a lyophilised 5 mg vial. Tested at 99.292% purity by an independent laboratory. Certificate published under lot 7678381156.
99+
Every lot goes to an independent laboratory for HPLC purity and LC-MS identity before release.
24h
Orders placed before 2 PM Pacific leave the warehouse the same working day, tracked end to end.
COA
Read the certificate for the exact lot you will receive before you place the order, not after.
Certificate of analysis
The certificate here belongs to the vial you are ordering, not to a representative batch. Purity by HPLC, identity by LC-MS and endotoxin screening, run by an independent laboratory.
Lyophilised powder is stable at ambient temperature in transit. On arrival, store sealed vials in a cool, dry, dark place. For storage beyond three months, keep at −20 °C.
Add bacteriostatic water slowly down the inner vial wall. Do not shake — swirl gently until fully dissolved.
Refrigerate at 2–8 °C and protect from light. Use within 30 days. Discard if the solution becomes cloudy or discoloured.
For laboratory research use only. Not for human or veterinary consumption. Not a drug or dietary supplement.
Research record · preclinical
Semax is a synthetic heptapeptide derived from an adrenocorticotropic hormone (ACTH) fragment, studied as a neuroactive research peptide that modulates neurotrophic and neurotransmitter-related signaling pathways in experimental models. Researchers buy Semax to investigate regulatory mechanisms distinct from classical receptor agonists or single-pathway peptides. Pure Forge Labs supplies high-purity Semax tested by independent labs for consistent quality. Strictly for research use only.
01
The heptapeptide comprises the 4-7 sequence of the N-terminal domain of adrenocorticotropic hormone with a C-terminal Pro-Gly-Pro tripeptide, a construction studied for its resistance to enzymatic degradation relative to the parent fragment. Work on N-terminal acetylation examined how the modification changes copper(II) and zinc(II) coordination and the associated properties.
02
RNA-Seq studies in a transient middle cerebral artery occlusion model identified differentially expressed genes associated with ACTH(4-7)PGP in the ipsilateral frontal cortex, with follow-up work comparing brain regions of differing ischaemic damage. These reports characterise transcriptional response rather than clinical outcome.
03
A 2025 study in mice reported the peptide targeting the μ opioid receptor gene Oprm1 with effects on deubiquitination in a spinal cord injury model. Separately, a resting-state fMRI study in 52 healthy participants measured whole-brain functional connectivity before and after administration, alongside Selank and placebo.
| Research area | Assay |
|---|---|
| Peptide chemistry | Copper(II) and zinc(II) coordination of the native and acetylated peptide |
| Transcriptional profiling | RNA-Seq of rat brain regions after experimental ischaemia |
| Receptor signalling | Oprm1 targeting and deubiquitination readouts |
| Functional connectivity | Resting-state fMRI of amygdala and dorsolateral prefrontal cortex |
| Comparative pharmacology | Side-by-side profiling with the tuftsin analogue Selank |
A large part of this literature originates from a small number of Russian research groups, and the imaging work covers acute administration in healthy volunteers rather than a clinical endpoint. The compound holds no FDA approval.
2D structure · PubChem CID 122178
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Every compound we sell is supplied for laboratory research and development only. It is not a drug, not a supplement, and not intended to diagnose, treat, cure or prevent any condition in humans or animals. Buying from this site means you are acquiring it for in vitro or other controlled research work.
Purchasers must be 21 or older and are responsible for compliance with the law where they take delivery. We ship to research institutions, laboratories and qualified individual researchers. We do not ship to jurisdictions where these compounds are restricted.
Check three things in order. First, the lot code on the certificate matches the code printed on your vial. Second, the HPLC chromatogram shows a single dominant peak with the stated purity figure. Third, the LC-MS mass matches the expected molecular weight, here 1419.56 g/mol. Anything that does not line up, send us the lot code.
Add bacteriostatic water slowly down the inner wall of the vial and swirl — never shake. Once in solution, refrigerate at 2–8 °C, protect from light and use within 30 days. Unopened vials keep at ambient temperature short term, or at −20 °C beyond three months.
Orders placed before 2 PM Pacific dispatch the same working day. Domestic delivery is two days, with tracking sent on dispatch. Shipping is free on orders over $200. International orders go out with a commercial invoice; transit is typically five to nine days.
Institutional purchase orders and bank transfer are available on wholesale accounts — apply through the wholesale programme and we will set up terms.
Photograph the vial and outer packaging and email us within 48 hours of delivery. We replace damaged or compromised vials at our cost. Unopened vials can be returned within 30 days; opened vials cannot be resold and are not returnable.
Yes. Volume pricing on this page runs to five vials; beyond that, a wholesale account gives tiered pricing, reserved lots and consolidated shipping. Reserved lots matter for multi-month studies where you need the same batch throughout.
FOR RESEARCH USE ONLY. NOT FOR HUMAN OR VETERINARY CONSUMPTION. This product is intended solely for legitimate laboratory, analytical, and scientific research. It is not intended to diagnose, treat, cure, mitigate, or prevent any disease and is not intended for human or veterinary administration or consumption. All products are intended for research and identification purposes only. These products are not intended for human dosing, injection, or ingestion.
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