Peptides > 99.98% purity Research Use Only · Not for Human or Veterinary Consumption

Glutathione

Glutathione supplied as a lyophilised 600 mg vial. Tested at > 99.98% purity by an independent laboratory. Certificate published under lot 3335563937.

Purity: > 99.98% HPLC
Mol. weight: 307.32 g/mol
Current lot: 3335563937 COA →

$57.99 $39.99 per vial, 600 mg

Quantity — volume pricing

Reconstitution Solution – for Laboratory Use Bacteriostatic · needed to reconstitute +$9.99

In stock · ships today Lot 3335563937 View COA →

99+

Third-party purity

Every lot goes to an independent laboratory for HPLC purity and LC-MS identity before release.

24h

Same-day dispatch

Orders placed before 2 PM Pacific leave the warehouse the same working day, tracked end to end.

COA

Published before purchase

Read the certificate for the exact lot you will receive before you place the order, not after.

Certificate of analysis

Every vial ships against its own lot

The certificate here belongs to the vial you are ordering, not to a representative batch. Purity by HPLC, identity by LC-MS and endotoxin screening, run by an independent laboratory.

Download PDF All lots for Glutathione

Lot 3335563937

Purity > 99.98% HPLC

Identity Conforms by RP-HPLC with UV detection

Endotoxin < 11.25 EU/vial

Laboratory Chromate

Tested May 11, 2026

coa scan

Specification

Purity: > 99.98% by HPLC
Sequence: Listed on lot certificate
CAS number: 70-18-8
Molecular weight: 307.32 g/mol
Molecular formula: C10H17N3O6S
Physical form: Lyophilised white powder
Net quantity: 600 mg per vial
Current lot: 3335563937
Tested by: Chromate
SKU: PFL-GLUTATHIONE-600-MG

Storage & reconstitution

Before opening

Lyophilised powder is stable at ambient temperature in transit. On arrival, store sealed vials in a cool, dry, dark place. For storage beyond three months, keep at −20 °C.

Reconstitution

Add bacteriostatic water slowly down the inner vial wall. Do not shake — swirl gently until fully dissolved.

After reconstitution

Refrigerate at 2–8 °C and protect from light. Use within 30 days. Discard if the solution becomes cloudy or discoloured.

For laboratory research use only. Not for human or veterinary consumption. Not a drug or dietary supplement.

Research record · preclinical

Three characterised lines of work

Glutathione is a naturally occurring tripeptide composed of glutamine cysteine and glycine. It has been studied for its role in cellular processes such as antioxidant activity detoxification and maintaining cellular health. Research has focused on its potential involvement in supporting redox balance protecting cells from oxidative stress and participating in various metabolic pathways.

Biosynthesis and its rate limits

The tripeptide is assembled in the cytosol from glutamate, cysteine and glycine by two enzymes in sequence: glutamate cysteine ligase, made up of a catalytic and a modifier subunit, and then glutathione synthetase. Synthesis is described as regulated primarily by the activity of the first enzyme, by the availability of cysteine, and by feedback inhibition from the product itself, with transcriptional control reported through Nrf2 acting at the antioxidant response element, along with AP-1 and NF-κB.

Biochim Biophys Acta 2013 J Nutr 2004

Redox couple and enzyme partners

Glutathione and its disulfide are described as the major redox couple in animal cells. Reviews are specific that the antioxidant function is substantially accomplished through glutathione-dependent enzymes rather than by direct scavenging alone: glutathione peroxidase-catalysed reduction of hydrogen peroxide, organic and lipid hydroperoxides and peroxynitrite, with peroxiredoxins contributing. Glutathione peroxidase-1 is a selenoenzyme, and glutathione is what supplies its reducing equivalents.

Ageing Res Rev 2023 Free Radic Biol Med 2022

Mitochondrial pool

Synthesis takes place in the cytoplasm, from where the tripeptide is delivered to mitochondria and handles hydrogen peroxide inside them. Work on this pool describes a long-term imbalance between mitochondrial reactive oxygen species and the mitochondrial glutathione available to meet them as leading to cell dysfunction and to several distinct forms of cell death, including apoptosis, necroptosis and ferroptosis.

Int J Mol Sci 2024

In vitro applications

Research area	Assay
Biosynthesis	Glutamate cysteine ligase and glutathione synthetase activity assays
Redox status	Ratio of glutathione to glutathione disulfide in cells and tissue
Enzyme partners	Glutathione peroxidase and peroxiredoxin activity
Mitochondrial pool	Hydrogen peroxide handling within isolated mitochondria
Precursor supply	Cysteine, cystine, methionine and N-acetylcysteine as substrates

Two findings sit against the way this compound is commonly marketed. A 2016 review of glutathione as a skin-lightening agent found a dichotomy between the claims made for it and the evidence behind them, and stated that although intravenous injection is popular there is no evidence proving its efficacy for that purpose. Separately, work on cancer metabolism describes elevated glutathione as favouring tumour progression, correlating with increased metastasis and conferring resistance to treatment, which makes it a target for depletion rather than supplementation in that setting. The compound holds no FDA approval.

Structure

2D structure · PubChem CID 124886

References

1 Forman HJ, Zhang H, Rinna A (2009) Glutathione: overview of its protective roles, measurement, and biosynthesis. Mol Aspects Med. 10.1016/j.mam.2008.08.006
2 Lu SC (2013) Glutathione synthesis. Biochim Biophys Acta. 10.1016/j.bbagen.2012.09.008
3 Wu G et al. (2004) Glutathione metabolism and its implications for health. J Nutr. 10.1093/jn/134.3.489
4 Lapenna D (2023) Glutathione and glutathione-dependent enzymes: from biochemistry to gerontology. Ageing Res Rev. 10.1016/j.arr.2023.102066
5 Handy DE, Loscalzo J (2022) The role of glutathione peroxidase-1 in health and disease. Free Radic Biol Med. 10.1016/j.freeradbiomed.2022.06.004
6 Chen TH et al. (2024) Mitochondrial glutathione in cellular redox homeostasis and disease manifestation. Int J Mol Sci. 10.3390/ijms25021314
7 Sonthalia S, Daulatabad D, Sarkar R (2016) Glutathione as a skin whitening agent: facts, myths, evidence and controversies. Indian J Dermatol Venereol Leprol. 10.4103/0378-6323.179088
8 Bansal A, Simon MC (2018) Glutathione metabolism in cancer progression and treatment resistance. J Cell Biol. 10.1083/jcb.201804161

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Common questions

Ordering, handling and compliance. Anything not covered here, write to support@pureforgelabs.com.

What does research use only actually mean?

Every compound we sell is supplied for laboratory research and development only. It is not a drug, not a supplement, and not intended to diagnose, treat, cure or prevent any condition in humans or animals. Buying from this site means you are acquiring it for in vitro or other controlled research work.

Who is allowed to order?

Purchasers must be 21 or older and are responsible for compliance with the law where they take delivery. We ship to research institutions, laboratories and qualified individual researchers. We do not ship to jurisdictions where these compounds are restricted.

How do I read the certificate of analysis?

Check three things in order. First, the lot code on the certificate matches the code printed on your vial. Second, the HPLC chromatogram shows a single dominant peak with the stated purity figure. Third, the LC-MS mass matches the expected molecular weight, here 1419.56 g/mol. Anything that does not line up, send us the lot code.

How do I reconstitute and store it?

Add bacteriostatic water slowly down the inner wall of the vial and swirl — never shake. Once in solution, refrigerate at 2–8 °C, protect from light and use within 30 days. Unopened vials keep at ambient temperature short term, or at −20 °C beyond three months.

When does it ship and how?

Orders placed before 2 PM Pacific dispatch the same working day. Domestic delivery is two days, with tracking sent on dispatch. Shipping is free on orders over $200. International orders go out with a commercial invoice; transit is typically five to nine days.

What payment methods do you take?

Institutional purchase orders and bank transfer are available on wholesale accounts — apply through the wholesale programme and we will set up terms.

What if a vial arrives damaged?

Photograph the vial and outer packaging and email us within 48 hours of delivery. We replace damaged or compromised vials at our cost. Unopened vials can be returned within 30 days; opened vials cannot be resold and are not returnable.

Do you handle bulk and wholesale orders?

Yes. Volume pricing on this page runs to five vials; beyond that, a wholesale account gives tiered pricing, reserved lots and consolidated shipping. Reserved lots matter for multi-month studies where you need the same batch throughout.

FOR RESEARCH USE ONLY. NOT FOR HUMAN OR VETERINARY CONSUMPTION. This product is intended solely for legitimate laboratory, analytical, and scientific research. It is not intended to diagnose, treat, cure, mitigate, or prevent any disease and is not intended for human or veterinary administration or consumption. All products are intended for research and identification purposes only. These products are not intended for human dosing, injection, or ingestion.

$39.99

Glutathione · 600 mg · 1 vial

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