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Thymosin Alpha-1 supplied as a lyophilised 10 mg vial. Tested at 99.17% purity by an independent laboratory. Certificate published under lot RP218-16Mar26-14.
98+
Every lot has a certificate from an independent laboratory, typically for HPLC purity and identity.
1–3
Orders are usually prepared for shipment within 1–3 business days, then tracked end to end.
COA
Read the latest certificate for the compound before you place the order, not after.
Certificate of analysis
The certificate of analysis an independent laboratory issued for the lot listed here: typically purity by HPLC and identity, and endotoxins where the laboratory tested them.
Lyophilised powder is stable at ambient temperature in transit. On arrival, keep sealed vials refrigerated at 2–8 °C, dry and dark. For storage beyond three months, keep at −20 °C.
Follow your laboratory's own protocol.
Refrigerate at 2–8 °C and protect from light. Use within 30 days. Discard if the solution becomes cloudy or discoloured.
For laboratory research use only. Not for human or veterinary consumption. Not a drug or dietary supplement.
Research record
Thymosin Alpha 1 is a synthetic peptide that has been studied for its role in modulating immune pathways and cellular processes. Research has explored its potential applications in areas such as immune response cellular signaling and mechanisms related to homeostasis and tissue dynamics. Its properties have made it a focus of interest in studies involving regulatory functions within biological systems.
01
A synthetic polypeptide described as modulating the immune system by augmenting T-cell function, with the proposed route being an action on thymocytes that either stimulates their differentiation or converts them to active T cells. The pharmacokinetics reported in the same review are short: rapid absorption with peak serum concentrations within two hours, a serum half-life of roughly two hours, and a return to baseline within 24 hours.
02
This is where the clinical literature is densest. A 2001 review summarised 195 patients across four trials, including one study reporting hepatitis B virus DNA clearance at six months in 9 of 17 patients given the peptide against 10 of 16 given interferon alfa-2b and 4 of 15 historical controls, and an open-label trial reporting clearance in 53 percent at six months. A 2015 review of the subsequent work describes monotherapy as suppressing viral replication relative to untreated controls or conventional interferon, with combination against lamivudine or interferon alfa reported to show better DNA suppression and HBeAg seroconversion.
03
A review of sepsis studies reports reduced mortality, improved HLA-DR expression on monocytes and fewer secondary infections with the peptide alone or in combination, while stating that sepsis is heterogeneous enough that these results cannot be generalised to all patients. An open-label randomised pilot in 49 hospitalised patients with COVID-19 found higher incidence of clinical recovery in the treated group on both low-flow and high-flow oxygen, but neither difference reached significance, with the clearer signal being a 3.84-fold greater rise in CD4+ T cells by day 5 in the low-flow stratum.
| Research area | Assay |
|---|---|
| Macrophage polarisation | M2 phenotype after oncolytic adenovirus in tumour models |
| Structural characterisation | Circular dichroism, NMR and crystallography of an intrinsically unstructured peptide |
The clinical trials behind this compound are in chronic hepatitis B, sepsis and COVID-19, which are not the settings it is generally marketed for. Where the trials are recent they are small and cautious about themselves: the COVID-19 pilot ran to 49 patients and its recovery differences did not reach significance in either oxygen stratum, and the sepsis review states plainly that its results cannot be generalised across so heterogeneous a syndrome. The compound holds no FDA approval.
Regulatory status as of October 2026.
2D structure · PubChem CID 16130571
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Every compound we sell is supplied for laboratory research and development only. It is not a drug, not a supplement, and not intended to diagnose, treat, cure or prevent any condition in humans or animals. Buying from this site means you are acquiring it for in vitro or other controlled research work.
Purchasers must be 21 or older and are responsible for compliance with the law where they take delivery. We ship to research institutions, laboratories and qualified individual researchers in the United States only. We do not ship to jurisdictions where these compounds are restricted.
Check three things in order. First, the lot code on the certificate matches the lot listed on the product page and in your order. Second, where the report gives an HPLC purity, its chromatogram shows a single dominant peak at the stated figure; a blend's report shows a peak for each compound. Third, where the lab ran mass spectrometry, the measured mass matches the expected molecular weight of the compound. Anything that does not line up, send us the lot code.
Unopened vials keep at ambient temperature short term, as in transit; on arrival, refrigerate them at 2–8 °C, and keep them at −20 °C beyond three months. Reconstitute following your laboratory's own protocol; once in solution, refrigerate at 2–8 °C, protect from light and use within 30 days.
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