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TB-500 supplied as a lyophilised 10 mg vial. Tested at 99.573% purity by an independent laboratory. Certificate published under lot #148939.
98+
Every lot has a certificate from an independent laboratory, typically for HPLC purity and identity.
1–3
Orders are usually prepared for shipment within 1–3 business days, then tracked end to end.
COA
Read the latest certificate for the compound before you place the order, not after.
Certificate of analysis
The certificate of analysis an independent laboratory issued for the lot listed here: typically purity by HPLC and identity, and endotoxins where the laboratory tested them.
Lyophilised powder is stable at ambient temperature in transit. On arrival, keep sealed vials refrigerated at 2–8 °C, dry and dark. For storage beyond three months, keep at −20 °C.
Follow your laboratory's own protocol.
Refrigerate at 2–8 °C and protect from light. Use within 30 days. Discard if the solution becomes cloudy or discoloured.
For laboratory research use only. Not for human or veterinary consumption. Not a drug or dietary supplement.
Research record
TB-500, as supplied here, is thymosin beta-4 (Tβ4): the 43-residue, N-terminally acetylated peptide that binds monomeric actin and is the main actin-sequestering peptide of mammalian cells. The laboratory report for the current lot identifies full-length Tβ4, not the 17–23 fragment that is sometimes sold under the same name. Researchers use it in preclinical models of cell migration, actin dynamics and tissue repair.
01
The identified molecular function of thymosin β4 is sequestration of G-actin. The dissociation constant of the complex sits in the micromolar range, which allows fast binding and release, and β-thymosins are described as the main intracellular G-actin-sequestering peptides in most cells. This is the one activity with an explanation grounded in a defined molecular interaction.
02
Overexpression or addition of exogenous thymosin β4, or its homologue β10, alters the actin cytoskeleton and has multiple effects on functions related to cell motility. Reviews note that some of these effects are consistent with a monomer-binding protein acting alone and others are not, leaving direct and indirect contributions unresolved.
03
In preclinical cardiac ischaemia models, treatment reduced infarct volume and preserved function, with antifibrotic and proangiogenic activity reported separately from infarct size. Reviews attribute the breadth of effects to interaction with several signalling pathways, in particular indirect regulation of motility through the SRF-MRTF-G-actin transcriptional route.
| Research area | Assay |
|---|---|
| Actin dynamics | G-actin binding and sequestration assays |
| Cell migration | Motility and outgrowth readouts in culture |
| Angiogenesis | Vessel formation in preclinical cardiac and tissue models |
| Fibrosis | Myofibroblast and scar-formation readouts |
| Structural characterisation | Circular dichroism and NMR of an intrinsically unstructured peptide |
Reviews note variable effect sizes across animal models, attributed in part to variable distribution, and call for pharmacokinetic and pharmacodynamic work before clinical development. The compound holds no FDA approval.
Regulatory status as of October 2026.
2D structure · PubChem CID 16132341
Ordering, handling and compliance. Anything not covered here, write to support@pureforgelabs.com.
Every compound we sell is supplied for laboratory research and development only. It is not a drug, not a supplement, and not intended to diagnose, treat, cure or prevent any condition in humans or animals. Buying from this site means you are acquiring it for in vitro or other controlled research work.
Purchasers must be 21 or older and are responsible for compliance with the law where they take delivery. We ship to research institutions, laboratories and qualified individual researchers in the United States only. We do not ship to jurisdictions where these compounds are restricted.
Check three things in order. First, the lot code on the certificate matches the lot listed on the product page and in your order. Second, where the report gives an HPLC purity, its chromatogram shows a single dominant peak at the stated figure; a blend's report shows a peak for each compound. Third, where the lab ran mass spectrometry, the measured mass matches the expected molecular weight of the compound. Anything that does not line up, send us the lot code.
Unopened vials keep at ambient temperature short term, as in transit; on arrival, refrigerate them at 2–8 °C, and keep them at −20 °C beyond three months. Reconstitute following your laboratory's own protocol; once in solution, refrigerate at 2–8 °C, protect from light and use within 30 days.
Orders are normally prepared for shipment within 1–3 business days and ship to street addresses in the United States only — not to P.O. boxes or APO/FPO/DPO military addresses. Shipping is free on orders over $150 and a flat $14.95 below that.
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