01
A pan-ERR agonist
Designing ERRα agonists had proved difficult; SLU-PP-332 came from work converting an ERRβ/γ-selective scaffold into pan agonists. It increased mitochondrial function and respiration in a skeletal muscle cell line, and in mice it increased type IIa oxidative fibres and exercise endurance through an ERRα-dependent acute aerobic exercise programme.






