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Semax 10 mg supplied as a lyophilised vial. Tested at 99.4% purity by an independent laboratory. Certificate published under lot KA-208514.
98+
Every lot has a certificate from an independent laboratory, typically for HPLC purity and identity.
1–3
Orders are usually prepared for shipment within 1–3 business days, then tracked end to end.
COA
Read the latest certificate for the compound before you place the order, not after.
Certificate of analysis
The certificate of analysis an independent laboratory issued for the lot listed here: typically purity by HPLC and identity, and endotoxins where the laboratory tested them.
Lyophilised powder is stable at ambient temperature in transit. On arrival, keep sealed vials refrigerated at 2–8 °C, dry and dark. For storage beyond three months, keep at −20 °C.
Follow your laboratory's own protocol.
Refrigerate at 2–8 °C and protect from light. Use within 30 days. Discard if the solution becomes cloudy or discoloured.
For laboratory research use only. Not for human or veterinary consumption. Not a drug or dietary supplement.
Research record
Semax is a synthetic heptapeptide derived from an adrenocorticotropic hormone (ACTH) fragment, studied as a neuroactive research peptide that modulates neurotrophic and neurotransmitter-related signaling pathways in experimental models. Researchers use Semax to investigate regulatory mechanisms distinct from classical receptor agonists or single-pathway peptides. Strictly for research use only.
01
The heptapeptide comprises the 4-7 sequence of the N-terminal domain of adrenocorticotropic hormone with a C-terminal Pro-Gly-Pro tripeptide, a construction studied for its resistance to enzymatic degradation relative to the parent fragment. Work on N-terminal acetylation examined how the modification changes copper(II) and zinc(II) coordination and the associated properties.
02
RNA-Seq studies in a transient middle cerebral artery occlusion model identified differentially expressed genes associated with ACTH(4-7)PGP in the ipsilateral frontal cortex, with follow-up work comparing brain regions of differing ischaemic damage. These reports characterise transcriptional response rather than clinical outcome.
03
A 2025 study in mice reported the peptide targeting the μ opioid receptor gene Oprm1 with effects on deubiquitination in a spinal cord injury model. Separately, a resting-state fMRI study in 52 healthy participants measured whole-brain functional connectivity before and after exposure to the peptide, alongside Selank and placebo.
| Research area | Assay |
|---|---|
| Peptide chemistry | Copper(II) and zinc(II) coordination of the native and acetylated peptide |
| Transcriptional profiling | RNA-Seq of rat brain regions after experimental ischaemia |
| Receptor signalling | Oprm1 targeting and deubiquitination readouts |
A large part of this literature originates from a small number of Russian research groups, and the imaging work covers acute exposure in healthy volunteers rather than a clinical endpoint. The compound holds no FDA approval.
Regulatory status as of October 2026.
2D structure · PubChem CID 122178
Ordering, handling and compliance. Anything not covered here, write to support@pureforgelabs.com.
Every compound we sell is supplied for laboratory research and development only. It is not a drug, not a supplement, and not intended to diagnose, treat, cure or prevent any condition in humans or animals. Buying from this site means you are acquiring it for in vitro or other controlled research work.
Purchasers must be 21 or older and are responsible for compliance with the law where they take delivery. We ship to research institutions, laboratories and qualified individual researchers in the United States only. We do not ship to jurisdictions where these compounds are restricted.
Check three things in order. First, the lot code on the certificate matches the lot listed on the product page and in your order. Second, where the report gives an HPLC purity, its chromatogram shows a single dominant peak at the stated figure; a blend's report shows a peak for each compound. Third, where the lab ran mass spectrometry, the measured mass matches the expected molecular weight of the compound. Anything that does not line up, send us the lot code.
Unopened vials keep at ambient temperature short term, as in transit; on arrival, refrigerate them at 2–8 °C, and keep them at −20 °C beyond three months. Reconstitute following your laboratory's own protocol; once in solution, refrigerate at 2–8 °C, protect from light and use within 30 days.
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FOR RESEARCH USE ONLY. NOT FOR HUMAN OR VETERINARY CONSUMPTION. This product is intended solely for legitimate laboratory, analytical, and scientific research. It is not intended to diagnose, treat, cure, mitigate, or prevent any disease and is not intended for human or veterinary administration or consumption. All products are intended for research and identification purposes only. These products are not intended for human dosing, injection, or ingestion.
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