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KPV supplied as a lyophilised 10 mg vial. Tested at 99.39% purity by an independent laboratory. Certificate published under lot RP218-16Mar26-5.
98+
Every lot has a certificate from an independent laboratory, typically for HPLC purity and identity.
1–3
Orders are usually prepared for shipment within 1–3 business days, then tracked end to end.
COA
Read the latest certificate for the compound before you place the order, not after.
Certificate of analysis
The certificate of analysis an independent laboratory issued for the lot listed here: typically purity by HPLC and identity, and endotoxins where the laboratory tested them.
Lyophilised powder is stable at ambient temperature in transit. On arrival, keep sealed vials refrigerated at 2–8 °C, dry and dark. For storage beyond three months, keep at −20 °C.
Follow your laboratory's own protocol.
Refrigerate at 2–8 °C and protect from light. Use within 30 days. Discard if the solution becomes cloudy or discoloured.
For laboratory research use only. Not for human or veterinary consumption. Not a drug or dietary supplement.
Research record
KPV (Lys-Pro-Val) is a tripeptide frequently referenced as an α-MSH fragment (11–13) in experimental literature. Due to its size and stability relative to longer peptides, KPV is commonly used as a research peptide when evaluating peptide signaling hypotheses tied to melanocortin-adjacent pathways and immune/inflammation signaling markers in controlled assays.
01
In immortalised human bronchial epithelial cells the tripeptide produced dose-dependent inhibition of NF-κB signalling evoked by TNFα and respiratory syncytial virus, alongside reduced matrix metalloproteinase-9 activity and lower IL-8 and eotaxin secretion. The effect was associated with nuclear import of the peptide, stabilisation of IκBα and suppressed nuclear translocation of p65RelA, with competition assays indicating an interaction at the importin-α3 binding site.
02
Work in intestinal models describes uptake of the tripeptide through the PepT1 di- and tripeptide transporter, with reduced inflammatory readouts reported downstream of that route. This is the basis on which the fragment is examined separately from the parent hormone: it enters cells by a transporter that longer melanocortin peptides do not use.
03
The sequence corresponds to residues 11-13 of α-melanocyte-stimulating hormone. Reviews of the parent hormone place the fragment among the C-terminal sequences that retain activity in inflammatory readouts, and report inhibitory activity for both α-MSH and KPV against Staphylococcus aureus and Candida albicans in antimicrobial assays.
| Research area | Assay |
|---|---|
| NF-κB signalling | p65RelA translocation and IκBα stability in bronchial epithelial culture |
| Inflammatory markers | IL-8, eotaxin and MMP-9 readouts after TNFα or viral challenge |
| Keratinocyte models | Apoptosis and MAPK/NF-κB readouts under particulate-matter exposure |
| Transporter uptake | PepT1-mediated transport in intestinal epithelial models |
| Analytical stability | Stability-indicating HPLC in aqueous solution and skin homogenate |
The record for this tripeptide is preclinical and largely in vitro. Much of it sits within the wider literature on α-MSH rather than on the fragment alone, and the compound holds no FDA approval.
Regulatory status as of October 2026.
2D structure · PubChem CID 125672
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Every compound we sell is supplied for laboratory research and development only. It is not a drug, not a supplement, and not intended to diagnose, treat, cure or prevent any condition in humans or animals. Buying from this site means you are acquiring it for in vitro or other controlled research work.
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Check three things in order. First, the lot code on the certificate matches the lot listed on the product page and in your order. Second, where the report gives an HPLC purity, its chromatogram shows a single dominant peak at the stated figure; a blend's report shows a peak for each compound. Third, where the lab ran mass spectrometry, the measured mass matches the expected molecular weight of the compound. Anything that does not line up, send us the lot code.
Unopened vials keep at ambient temperature short term, as in transit; on arrival, refrigerate them at 2–8 °C, and keep them at −20 °C beyond three months. Reconstitute following your laboratory's own protocol; once in solution, refrigerate at 2–8 °C, protect from light and use within 30 days.
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