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Secretagogue receptor route
The original characterisation describes a pentapeptide identified within a series of compounds lacking the central Ala-Trp dipeptide of GHRP-1. In primary rat pituitary cells it released growth hormone with potency and efficacy reported as similar to GHRP-6, at an EC50 of 1.3 nmol/l against 2.2 nmol/l. Profiling with GHRP and GHRH antagonists indicated that release proceeds through a GHRP-like receptor rather than the GHRH receptor, which is the basis on which the compound is separated from the GHRH analogues sold alongside it.
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