Age verification
VIP 10 mg supplied as a lyophilised vial. Tested at 99.79% purity by an independent laboratory. Certificate published under lot COA8306.
98+
Every lot has a certificate from an independent laboratory, typically for HPLC purity and identity.
1–3
Orders are usually prepared for shipment within 1–3 business days, then tracked end to end.
COA
Read the latest certificate for the compound before you place the order, not after.
Certificate of analysis
The certificate of analysis an independent laboratory issued for the lot listed here: typically purity by HPLC and identity, and endotoxins where the laboratory tested them.
Lyophilised powder is stable at ambient temperature in transit. On arrival, keep sealed vials refrigerated at 2–8 °C, dry and dark. For storage beyond three months, keep at −20 °C.
Follow your laboratory's own protocol.
Refrigerate at 2–8 °C and protect from light. Use within 30 days. Discard if the solution becomes cloudy or discoloured.
For laboratory research use only. Not for human or veterinary consumption. Not a drug or dietary supplement.
Research record
Vasoactive intestinal peptide (VIP) is an endogenous 28-amino-acid neuropeptide of the central and peripheral nervous systems, where it acts as a non-adrenergic, non-cholinergic neurotransmitter or neuromodulator. It signals through two G protein-coupled receptors, VPAC1 and VPAC2, and is studied in vascular, circadian, metabolic and immune research.
01
On a molar basis the peptide is reported to be 50 to 100 times more potent than acetylcholine as a vasodilator. It dose-dependently activates adenylyl cyclase; VIP-containing nerve fibres reach the coronary vessels, the sinoatrial and atrioventricular nodes and the ventricles, and in the coronary circulation the peptide increases coronary blood flow, with positive inotropic and chronotropic effects.
02
Within the hypothalamic suprachiasmatic nucleus VIP defines a population of neurons, and loss of the peptide or of its VPAC2 receptor strongly affects the ability of these neurons to generate and synchronise circadian oscillations. Acting through VPAC2 it modulates synaptic transmission and intrinsic membrane currents.
03
Through VPAC2 the peptide stimulates glucose-dependent insulin secretion and promotes beta-cell proliferation through the forkhead box M1 pathway; its short half-life has led to VPAC2-selective agonists being developed instead. In antigen-presenting cells it down-regulates innate responses, suppressing pro-inflammatory cytokine secretion and surface marker expression.
| Research area | Assay |
|---|---|
| Receptor signalling | Adenylyl cyclase and cAMP readouts at VPAC1 and VPAC2 |
| Vascular tone | Vasodilation and coronary flow in isolated vessel and heart preparations |
| Circadian biology | Rhythm generation and synchrony in suprachiasmatic nucleus neurons |
| Islet function | Glucose-dependent insulin secretion |
| Immune modulation | Cytokine and surface marker expression in antigen-presenting cells |
The peptide's short half-life and wide distribution are cited as limits on its use outside the laboratory. What sustained excess does is known from VIP-secreting tumours: refractory watery diarrhoea, low potassium and metabolic acidosis. Most of the record concerns the endogenous peptide and its receptors rather than exogenous VIP, and the compound holds no FDA approval.
Regulatory status as of October 2026.
2D structure · PubChem CID 16140438
Ordering, handling and compliance. Anything not covered here, write to support@pureforgelabs.com.
Every compound we sell is supplied for laboratory research and development only. It is not a drug, not a supplement, and not intended to diagnose, treat, cure or prevent any condition in humans or animals. Buying from this site means you are acquiring it for in vitro or other controlled research work.
Purchasers must be 21 or older and are responsible for compliance with the law where they take delivery. We ship to research institutions, laboratories and qualified individual researchers in the United States only. We do not ship to jurisdictions where these compounds are restricted.
Check three things in order. First, the lot code on the certificate matches the lot listed on the product page and in your order. Second, where the report gives an HPLC purity, its chromatogram shows a single dominant peak at the stated figure; a blend's report shows a peak for each compound. Third, where the lab ran mass spectrometry, the measured mass matches the expected molecular weight of the compound. Anything that does not line up, send us the lot code.
Unopened vials keep at ambient temperature short term, as in transit; on arrival, refrigerate them at 2–8 °C, and keep them at −20 °C beyond three months. Reconstitute following your laboratory's own protocol; once in solution, refrigerate at 2–8 °C, protect from light and use within 30 days.
Orders are normally prepared for shipment within 1–3 business days and ship to street addresses in the United States only — not to P.O. boxes or APO/FPO/DPO military addresses. Shipping is free on orders over $150 and a flat $14.95 below that.
We take credit and debit cards, paid securely at checkout. Bank transfers and purchase orders are not available at the moment.
Keep the vial and all the packaging, photograph the damage and email support@pureforgelabs.com within 48 hours of delivery with your order number. Once the claim is verified, we replace the vial or refund what you paid for it. Please do not send anything back unless we ask you to — apart from damaged or incorrect items, all sales are final.
Yes, by quote. The volume tiers on the product pages go up to five vials; for larger research quantities email support@pureforgelabs.com with the compounds and amounts, and we will quote per gram.
FOR RESEARCH USE ONLY. NOT FOR HUMAN OR VETERINARY CONSUMPTION. This product is intended solely for legitimate laboratory, analytical, and scientific research. It is not intended to diagnose, treat, cure, mitigate, or prevent any disease and is not intended for human or veterinary administration or consumption. All products are intended for research and identification purposes only. These products are not intended for human dosing, injection, or ingestion.
One short email when something changes. No drip campaigns.
Damaged in transit, or not the product on your order? Email support@pureforgelabs.com within 48 hours of delivery with photos of the item and the package — once verified, we replace it or refund it. All other sales are final.
All compounds are sold for in-vitro laboratory research only. Not for human or veterinary use, not a drug or dietary supplement. By placing this order you confirm you are a qualified researcher aged 21 or over and that the material will not be administered to humans or animals.
