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TB-500 supplied as a lyophilised 5 mg vial. Tested at 98.32% purity by an independent laboratory. Certificate published under lot 4185039276.
99+
Every lot goes to an independent laboratory for HPLC purity and LC-MS identity before release.
24h
Orders placed before 2 PM Pacific leave the warehouse the same working day, tracked end to end.
COA
Read the certificate for the exact lot you will receive before you place the order, not after.
Certificate of analysis
The certificate here belongs to the vial you are ordering, not to a representative batch. Purity by HPLC, identity by LC-MS and endotoxin screening, run by an independent laboratory.
Lyophilised powder is stable at ambient temperature in transit. On arrival, store sealed vials in a cool, dry, dark place. For storage beyond three months, keep at −20 °C.
Add bacteriostatic water slowly down the inner vial wall. Do not shake — swirl gently until fully dissolved.
Refrigerate at 2–8 °C and protect from light. Use within 30 days. Discard if the solution becomes cloudy or discoloured.
For laboratory research use only. Not for human or veterinary consumption. Not a drug or dietary supplement.
Research record · preclinical
TB-500 is a synthetic peptide derived from a biologically active region of the naturally occurring protein Thymosin Beta-4 (Tβ4). Researchers investigate TB-500 in preclinical models involving cell migration, actin dynamics, cellular signaling, and tissue-associated biological processes. Pure Forge Labs is a U.S. peptide supplier offering high-purity TB-500, with verification by accredited third-party laboratories to ensure consistent batch quality Available Sizes: TB-500 is supplied as a high-purity, lyophilized powder in multiple sizes to support diverse research scales and experimental protocols:
01
The identified molecular function of thymosin β4 is sequestration of G-actin. The dissociation constant of the complex sits in the micromolar range, which allows fast binding and release, and β-thymosins are described as the main intracellular G-actin-sequestering peptides in most cells. This is the one activity with an explanation grounded in a defined molecular interaction.
02
Overexpression or addition of exogenous thymosin β4, or its homologue β10, alters the actin cytoskeleton and has multiple effects on functions related to cell motility. Reviews note that some of these effects are consistent with a monomer-binding protein acting alone and others are not, leaving direct and indirect contributions unresolved.
03
In preclinical cardiac ischaemia models, treatment reduced infarct volume and preserved function, with antifibrotic and proangiogenic activity reported separately from infarct size. Reviews attribute the breadth of effects to interaction with several signalling pathways, in particular indirect regulation of motility through the SRF-MRTF-G-actin transcriptional route.
| Research area | Assay |
|---|---|
| Actin dynamics | G-actin binding and sequestration assays |
| Cell migration | Motility and outgrowth readouts in culture |
| Angiogenesis | Vessel formation in preclinical cardiac and tissue models |
| Fibrosis | Myofibroblast and scar-formation readouts |
| Structural characterisation | Circular dichroism and NMR of an intrinsically unstructured peptide |
TB-500 is a fragment of thymosin β4, and much of the literature concerns the full peptide rather than the fragment sold here. Reviews note variable effect sizes across animal models, attributed in part to variable distribution, and call for pharmacokinetic and pharmacodynamic work before clinical development. The compound holds no FDA approval.
2D structure · PubChem CID 16132341
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Every compound we sell is supplied for laboratory research and development only. It is not a drug, not a supplement, and not intended to diagnose, treat, cure or prevent any condition in humans or animals. Buying from this site means you are acquiring it for in vitro or other controlled research work.
Purchasers must be 21 or older and are responsible for compliance with the law where they take delivery. We ship to research institutions, laboratories and qualified individual researchers. We do not ship to jurisdictions where these compounds are restricted.
Check three things in order. First, the lot code on the certificate matches the code printed on your vial. Second, the HPLC chromatogram shows a single dominant peak with the stated purity figure. Third, the LC-MS mass matches the expected molecular weight, here 1419.56 g/mol. Anything that does not line up, send us the lot code.
Add bacteriostatic water slowly down the inner wall of the vial and swirl — never shake. Once in solution, refrigerate at 2–8 °C, protect from light and use within 30 days. Unopened vials keep at ambient temperature short term, or at −20 °C beyond three months.
Orders placed before 2 PM Pacific dispatch the same working day. Domestic delivery is two days, with tracking sent on dispatch. Shipping is free on orders over $200. International orders go out with a commercial invoice; transit is typically five to nine days.
Institutional purchase orders and bank transfer are available on wholesale accounts — apply through the wholesale programme and we will set up terms.
Photograph the vial and outer packaging and email us within 48 hours of delivery. We replace damaged or compromised vials at our cost. Unopened vials can be returned within 30 days; opened vials cannot be resold and are not returnable.
Yes. Volume pricing on this page runs to five vials; beyond that, a wholesale account gives tiered pricing, reserved lots and consolidated shipping. Reserved lots matter for multi-month studies where you need the same batch throughout.
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FOR RESEARCH USE ONLY. NOT FOR HUMAN OR VETERINARY CONSUMPTION. This product is intended solely for legitimate laboratory, analytical, and scientific research. It is not intended to diagnose, treat, cure, mitigate, or prevent any disease and is not intended for human or veterinary administration or consumption. All products are intended for research and identification purposes only. These products are not intended for human dosing, injection, or ingestion.
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