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PT-141 supplied as a lyophilised 10 mg vial. Tested at 99.777% purity by an independent laboratory. Certificate published under lot 2218815796.
99+
Every lot goes to an independent laboratory for HPLC purity and LC-MS identity before release.
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Certificate of analysis
The certificate here belongs to the vial you are ordering, not to a representative batch. Purity by HPLC, identity by LC-MS and endotoxin screening, run by an independent laboratory.
Lyophilised powder is stable at ambient temperature in transit. On arrival, store sealed vials in a cool, dry, dark place. For storage beyond three months, keep at −20 °C.
Add bacteriostatic water slowly down the inner vial wall. Do not shake — swirl gently until fully dissolved.
Refrigerate at 2–8 °C and protect from light. Use within 30 days. Discard if the solution becomes cloudy or discoloured.
For laboratory research use only. Not for human or veterinary consumption. Not a drug or dietary supplement.
Research record · preclinical
PT-141 also known as Bremelanotide is a synthetic derivative of alpha-melanocyte-stimulating hormone. It has been studied for its interactions with melanocortin receptors particularly melanocortin-4 and melanocortin-1. Research has explored its potential role in influencing physiological processes such as sexual function and immune response as well as its broader effects within these pathways.
01
A synthetic analogue of the neuropeptide hormone alpha melanocyte-stimulating hormone, described as having high affinity for the melanocortin type 4 receptor, which is thought to be important for sexual function and gives the compound the potential to modulate brain pathways involved in sexual response. A 2023 review of the central melanocortin system places it alongside setmelanotide and afamelanotide as melanocortin-targeting peptides that reached approval.
02
The compound was first described in development as a nasal spray candidate for erectile dysfunction and female sexual dysfunction, with a phase IIb trial in erectile dysfunction completed in 2003 and phase III planned for 2005. It was approved in 2019 in a different form: a self-administered, on-demand subcutaneous therapy for premenopausal women with acquired, generalised hypoactive sexual desire disorder.
03
A safety review covering the whole development programme, 3500 subjects across 43 completed studies with phase 3 exposure of up to 18 months, gives the most common adverse events against placebo as nausea at 40.0 against 1.3 percent, flushing at 20.3 against 1.3 percent, headache at 11.3 against 1.9 percent and injection site reactions at 5.4 against 0.5 percent. Separately, a drug-induced liver injury monograph records mild serum enzyme elevations during therapy and rare instances of clinically apparent acute liver injury.
| Research area | Assay |
|---|---|
| Receptor binding | Melanocortin type 4 receptor affinity within the melanocortin family |
| Clinical endpoints | Desire and distress outcomes across the phase 3 programme |
| Adverse-event profile | Pooled safety data from 43 completed studies |
| Hepatic monitoring | Serum enzyme elevations in the drug-injury record |
| Comparative pharmacology | Positioning against other approved melanocortin agonists |
Bremelanotide holds an FDA approval, but a narrow one, and the rates in the third panel come from that approved dose in that trial population rather than from any other use: nausea was reported in 40 percent of treated participants against 1.3 percent on placebo. Reviews of the condition it was approved for describe its underlying physiology as still unknown. A lactation monograph records that no information is available on clinical use during breastfeeding, and advises caution on that basis rather than on evidence of harm.
2D structure · PubChem CID 9941379
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Check three things in order. First, the lot code on the certificate matches the code printed on your vial. Second, the HPLC chromatogram shows a single dominant peak with the stated purity figure. Third, the LC-MS mass matches the expected molecular weight, here 1419.56 g/mol. Anything that does not line up, send us the lot code.
Add bacteriostatic water slowly down the inner wall of the vial and swirl — never shake. Once in solution, refrigerate at 2–8 °C, protect from light and use within 30 days. Unopened vials keep at ambient temperature short term, or at −20 °C beyond three months.
Orders placed before 2 PM Pacific dispatch the same working day. Domestic delivery is two days, with tracking sent on dispatch. Shipping is free on orders over $200. International orders go out with a commercial invoice; transit is typically five to nine days.
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