Age verification
MOTS-c supplied as a lyophilised 10 mg vial. Tested at 99.49% purity by an independent laboratory. Certificate published under lot 5839201746.
99+
Every lot goes to an independent laboratory for HPLC purity and LC-MS identity before release.
24h
Orders placed before 2 PM Pacific leave the warehouse the same working day, tracked end to end.
COA
Read the certificate for the exact lot you will receive before you place the order, not after.
Certificate of analysis
The certificate here belongs to the vial you are ordering, not to a representative batch. Purity by HPLC, identity by LC-MS and endotoxin screening, run by an independent laboratory.
Lyophilised powder is stable at ambient temperature in transit. On arrival, store sealed vials in a cool, dry, dark place. For storage beyond three months, keep at −20 °C.
Add bacteriostatic water slowly down the inner vial wall. Do not shake — swirl gently until fully dissolved.
Refrigerate at 2–8 °C and protect from light. Use within 30 days. Discard if the solution becomes cloudy or discoloured.
For laboratory research use only. Not for human or veterinary consumption. Not a drug or dietary supplement.
Research record · preclinical
A mitochondria-derived, 16-amino-acid peptide encoded by a short open reading frame within the mitochondrial 12S rRNA gene. MOTS-c is widely used in preclinical research to probe cellular stress responses and energy-sensing pathways (notably AMPK), as well as exercise and aging biology.
01
MOTS-c is a 16-amino-acid peptide encoded by a short open reading frame in the 12S rRNA region of the mitochondrial genome. Its identification followed that of humanin and established that the mitochondrial genome encodes more than one signalling peptide. Circulating levels are reported to decline with age.
02
Under metabolic stress the peptide translocates to the nucleus and regulates nuclear gene expression, described as a retrograde mitochondrial signal. This is unusual in the direction of information flow: the nuclear genome is not otherwise known to be actively controlled by factors encoded in mitochondrial DNA.
03
The original report described effects on metabolic homeostasis, obesity and insulin resistance in mice, with the folate-methionine cycle and AMPK signalling proposed as the route. Later work reports MYH9-dependent nuclear translocation with transcriptional activation of antioxidant genes in a lung ischaemia-reperfusion model.
| Research area | Assay |
|---|---|
| Peptide identification | Short open reading frame detection in mitochondrial DNA |
| Nuclear translocation | Subcellular localisation under metabolic stress |
| Metabolic readouts | Glucose metabolism and insulin sensitivity in skeletal muscle models |
| Antioxidant transcription | MYH9-dependent activation of antioxidant gene expression |
| Circulating levels | Plasma quantification across age and disease cohorts |
The record is preclinical, largely in rodent and cell models, and reviews note that no effective method of clinical application has been established. The compound holds no FDA approval.
2D structure · PubChem CID 146675088
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Every compound we sell is supplied for laboratory research and development only. It is not a drug, not a supplement, and not intended to diagnose, treat, cure or prevent any condition in humans or animals. Buying from this site means you are acquiring it for in vitro or other controlled research work.
Purchasers must be 21 or older and are responsible for compliance with the law where they take delivery. We ship to research institutions, laboratories and qualified individual researchers. We do not ship to jurisdictions where these compounds are restricted.
Check three things in order. First, the lot code on the certificate matches the code printed on your vial. Second, the HPLC chromatogram shows a single dominant peak with the stated purity figure. Third, the LC-MS mass matches the expected molecular weight, here 1419.56 g/mol. Anything that does not line up, send us the lot code.
Add bacteriostatic water slowly down the inner wall of the vial and swirl — never shake. Once in solution, refrigerate at 2–8 °C, protect from light and use within 30 days. Unopened vials keep at ambient temperature short term, or at −20 °C beyond three months.
Orders placed before 2 PM Pacific dispatch the same working day. Domestic delivery is two days, with tracking sent on dispatch. Shipping is free on orders over $200. International orders go out with a commercial invoice; transit is typically five to nine days.
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