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Peptides 99.701% purity Research Use Only · Not for Human or Veterinary Consumption

Melanotan II

Melanotan II supplied as a lyophilised 10 mg vial. Tested at 99.701% purity by an independent laboratory. Certificate published under lot 9740015007.

Purity: 99.701% HPLC
Mol. weight: 1024.18 g/mol
Current lot: 9740015007 COA →

$47.99 $32.99 per vial, 10 mg

Quantity — volume pricing

Reconstitution Solution – for Laboratory Use Bacteriostatic · needed to reconstitute +$9.99

In stock · ships today Lot 9740015007 View COA →

99+

Third-party purity

Every lot goes to an independent laboratory for HPLC purity and LC-MS identity before release.

24h

Same-day dispatch

Orders placed before 2 PM Pacific leave the warehouse the same working day, tracked end to end.

COA

Published before purchase

Read the certificate for the exact lot you will receive before you place the order, not after.

Certificate of analysis

Every vial ships against its own lot

The certificate here belongs to the vial you are ordering, not to a representative batch. Purity by HPLC, identity by LC-MS and endotoxin screening, run by an independent laboratory.

Download PDF All lots for Melanotan II

Lot 9740015007

Purity 99.701% HPLC

Identity Conforms by RP-HPLC with UV detection

Endotoxin < 1 EU/vial

Laboratory Chromate

Tested April 27, 2026

coa scan

Specification

Purity: 99.701% by HPLC
Sequence: Listed on lot certificate
CAS number: 121062-08-6
Molecular weight: 1024.18 g/mol
Molecular formula: C50H69N15O9
Physical form: Lyophilised white powder
Net quantity: 10 mg per vial
Current lot: 9740015007
Tested by: Chromate
SKU: PFL-MELANOTAN-II-10-MG

Storage & reconstitution

Before opening

Lyophilised powder is stable at ambient temperature in transit. On arrival, store sealed vials in a cool, dry, dark place. For storage beyond three months, keep at −20 °C.

Reconstitution

Add bacteriostatic water slowly down the inner vial wall. Do not shake — swirl gently until fully dissolved.

After reconstitution

Refrigerate at 2–8 °C and protect from light. Use within 30 days. Discard if the solution becomes cloudy or discoloured.

For laboratory research use only. Not for human or veterinary consumption. Not a drug or dietary supplement.

Research record · preclinical

Three characterised lines of work

Melanotan II is a synthetic cyclic peptide analog of alpha-melanocyte stimulating hormone (α-MSH) studied in research contexts. It functions by binding to several melanocortin receptors, including MC1R, MC3R, and MC4R. Through MC1R activation in melanocytes, it stimulates melanin production. The compound's interaction with MC3R and MC4R receptors has been associated with effects on appetite regulation and metabolic processes in research settings. Studies have also indicated that it may influence other physiological pathways through its binding to multiple receptor subtypes. The cyclic structure of Melanotan II gives it different binding characteristics compared to linear peptides, potentially affecting its interaction with receptor targets.

Melanocortin receptor agonism

The compound is a cyclic analogue of alpha-melanocyte-stimulating hormone, described in the medicinal chemistry literature as an unselective agonist of the human melanocortin receptors. Work on user-reported effects attributes the skin darkening to interaction at the melanocortin 1 receptor specifically. The lack of selectivity across the receptor family is the property that later chemistry set out to change, and it is also why the compound acts well beyond pigmentation.

J Med Chem 2022 Dermatology 2021

Scaffold for selective analogues

Because melanocortin receptors carry a pleiotropic role across physiological and pathological processes, medicinal chemists have used this peptide as the parent scaffold for agonists with improved selectivity. One study replaced its lactam cyclisation with xylene-derived thioethers and reported binding affinities from the low nanomolar to the sub-micromolar range, with a correlation between the linker explored and the affinity obtained. A separate line of work applies tryptathionine and bis-indole staples to the melanocortin peptide family, reporting nanomolar dissociation constants and one in the sub-nanomolar range.

J Med Chem 2022 Chemistry 2024

Behavioural model in zebrafish

The one in vivo report in this set examines diet rather than pigmentation. Zebrafish fed a high-fat diet for roughly one per cent of their lifespan showed impaired recognition memory, raised anxiety measures and reduced exploratory behaviour against controls after three weeks. Animals on the same diet given the peptide were described as returning to recognition memory, anxiety and exploratory behaviour similar to the control group. The authors note that studies of melanotropins in diet-induced neurobehavioural conditions were absent before this one.

Biomed Pharmacother 2023

In vitro applications

Research area	Assay
Receptor pharmacology	Binding across the human melanocortin receptor subtypes
Pigmentation	Melanocortin 1 receptor interaction and skin hyperpigmentation
Analogue design	Lactam cyclisation replaced by thioether and stapled scaffolds
Behavioural models	Recognition memory, anxiety and exploration in zebrafish
Analytical identity	HPLC-DAD and mass spectrometry against a reference standard

The safety literature is the most developed part of this compound's record, and it does not read in its favour. A 2020 case report attributes a renal infarction to Melanotan II and notes that rhabdomyolysis and renal failure had been described before it, proposing a thrombotic effect and possible direct toxicity as the routes. A 2014 report describes cutaneous melanoma in a 20-year-old who had completed a three- to four-week course of self-injections three months earlier alongside sunbed use. That is a single case with an obvious parallel exposure, and the authors' stated conclusion is the narrower one: the compound is unlicensed and incompletely tested, so the extent and types of adverse effect are unknown. Supply is a separate matter. A 2024 forensic analysis of vials labelled Melanotan II confirmed the identity against a reference standard and measured the purity at 30 per cent. What is known about how the compound is actually used comes from surveys of online forums rather than from trials. The compound holds no FDA approval.

Structure

2D structure · PubChem CID 92432

References

1 Tomassi S et al. (2022) CLIPSing Melanotan-II to discover multiple functionally selective hMCR agonists. J Med Chem. 10.1021/acs.jmedchem.1c01848
2 Todorovic M et al. (2024) Tryptathionine and bis-indole peptide staples: application to Melanotan-II. Chemistry. 10.1002/chem.202304270
3 Wekwejt P et al. (2023) Melanotan-II reverses memory impairment induced by a short-term high-fat diet. Biomed Pharmacother. 10.1016/j.biopha.2023.115129
4 Gilhooley E et al. (2021) Melanotan II user experience: a qualitative study of online discussion forums. Dermatology. 10.1159/000514492
5 Peters B et al. (2020) Melanotan II: a possible cause of renal infarction. CEN Case Rep. 10.1007/s13730-020-00447-z
6 Hjuler KF, Lorentzen HF (2014) Melanoma associated with the use of melanotan-II. Dermatology. 10.1159/000356389
7 Deville M, Charlier C (2024) Barbie drug identification: not a child's play. J Forensic Sci. 10.1111/1556-4029.15633
8 Callaghan DJ 3rd (2018) A glimpse into the underground market of melanotan. Dermatol Online J. PMID 30142729

Researcher notes

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Common questions

Ordering, handling and compliance. Anything not covered here, write to support@pureforgelabs.com.

What does research use only actually mean?

Every compound we sell is supplied for laboratory research and development only. It is not a drug, not a supplement, and not intended to diagnose, treat, cure or prevent any condition in humans or animals. Buying from this site means you are acquiring it for in vitro or other controlled research work.

Who is allowed to order?

Purchasers must be 21 or older and are responsible for compliance with the law where they take delivery. We ship to research institutions, laboratories and qualified individual researchers. We do not ship to jurisdictions where these compounds are restricted.

How do I read the certificate of analysis?

Check three things in order. First, the lot code on the certificate matches the code printed on your vial. Second, the HPLC chromatogram shows a single dominant peak with the stated purity figure. Third, the LC-MS mass matches the expected molecular weight, here 1419.56 g/mol. Anything that does not line up, send us the lot code.

How do I reconstitute and store it?

Add bacteriostatic water slowly down the inner wall of the vial and swirl — never shake. Once in solution, refrigerate at 2–8 °C, protect from light and use within 30 days. Unopened vials keep at ambient temperature short term, or at −20 °C beyond three months.

When does it ship and how?

Orders placed before 2 PM Pacific dispatch the same working day. Domestic delivery is two days, with tracking sent on dispatch. Shipping is free on orders over $200. International orders go out with a commercial invoice; transit is typically five to nine days.

What payment methods do you take?

Institutional purchase orders and bank transfer are available on wholesale accounts — apply through the wholesale programme and we will set up terms.

What if a vial arrives damaged?

Photograph the vial and outer packaging and email us within 48 hours of delivery. We replace damaged or compromised vials at our cost. Unopened vials can be returned within 30 days; opened vials cannot be resold and are not returnable.

Do you handle bulk and wholesale orders?

Yes. Volume pricing on this page runs to five vials; beyond that, a wholesale account gives tiered pricing, reserved lots and consolidated shipping. Reserved lots matter for multi-month studies where you need the same batch throughout.

FOR RESEARCH USE ONLY. NOT FOR HUMAN OR VETERINARY CONSUMPTION. This product is intended solely for legitimate laboratory, analytical, and scientific research. It is not intended to diagnose, treat, cure, mitigate, or prevent any disease and is not intended for human or veterinary administration or consumption. All products are intended for research and identification purposes only. These products are not intended for human dosing, injection, or ingestion.

$32.99

Melanotan II · 10 mg · 1 vial

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