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KPV supplied as a lyophilised 10 mg vial. Tested at 99.025% purity by an independent laboratory. Certificate published under lot 4636999077.
99+
Every lot goes to an independent laboratory for HPLC purity and LC-MS identity before release.
24h
Orders placed before 2 PM Pacific leave the warehouse the same working day, tracked end to end.
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Certificate of analysis
The certificate here belongs to the vial you are ordering, not to a representative batch. Purity by HPLC, identity by LC-MS and endotoxin screening, run by an independent laboratory.
Lyophilised powder is stable at ambient temperature in transit. On arrival, store sealed vials in a cool, dry, dark place. For storage beyond three months, keep at −20 °C.
Add bacteriostatic water slowly down the inner vial wall. Do not shake — swirl gently until fully dissolved.
Refrigerate at 2–8 °C and protect from light. Use within 30 days. Discard if the solution becomes cloudy or discoloured.
For laboratory research use only. Not for human or veterinary consumption. Not a drug or dietary supplement.
Research record · preclinical
KPV (Lys-Pro-Val) is a tripeptide frequently referenced as an α-MSH fragment (11–13) in experimental literature. Due to its size and stability relative to longer peptides, KPV is commonly used as a research peptide when evaluating peptide signaling hypotheses tied to melanocortin-adjacent pathways and immune/inflammation signaling markers in controlled assays. In-vitro assays tracking inflammatory marker expression Exploratory studies of melanocortin pathway signaling
01
In immortalised human bronchial epithelial cells the tripeptide produced dose-dependent inhibition of NF-κB signalling evoked by TNFα and respiratory syncytial virus, alongside reduced matrix metalloproteinase-9 activity and lower IL-8 and eotaxin secretion. The effect was associated with nuclear import of the peptide, stabilisation of IκBα and suppressed nuclear translocation of p65RelA, with competition assays indicating an interaction at the importin-α3 binding site.
02
Work in intestinal models describes uptake of the tripeptide through the PepT1 di- and tripeptide transporter, with reduced inflammatory readouts reported downstream of that route. This is the basis on which the fragment is examined separately from the parent hormone: it enters cells by a transporter that longer melanocortin peptides do not use.
03
The sequence corresponds to residues 11-13 of α-melanocyte-stimulating hormone. Reviews of the parent hormone place the fragment among the C-terminal sequences that retain activity in inflammatory readouts, and report inhibitory activity for both α-MSH and KPV against Staphylococcus aureus and Candida albicans in antimicrobial assays.
| Research area | Assay |
|---|---|
| NF-κB signalling | p65RelA translocation and IκBα stability in bronchial epithelial culture |
| Inflammatory markers | IL-8, eotaxin and MMP-9 readouts after TNFα or viral challenge |
| Keratinocyte models | Apoptosis and MAPK/NF-κB readouts under particulate-matter exposure |
| Transporter uptake | PepT1-mediated transport in intestinal epithelial models |
| Analytical stability | Stability-indicating HPLC in aqueous solution and skin homogenate |
The record for this tripeptide is preclinical and largely in vitro. Much of it sits within the wider literature on α-MSH rather than on the fragment alone, and the compound holds no FDA approval.
2D structure · PubChem CID 125672
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Every compound we sell is supplied for laboratory research and development only. It is not a drug, not a supplement, and not intended to diagnose, treat, cure or prevent any condition in humans or animals. Buying from this site means you are acquiring it for in vitro or other controlled research work.
Purchasers must be 21 or older and are responsible for compliance with the law where they take delivery. We ship to research institutions, laboratories and qualified individual researchers. We do not ship to jurisdictions where these compounds are restricted.
Check three things in order. First, the lot code on the certificate matches the code printed on your vial. Second, the HPLC chromatogram shows a single dominant peak with the stated purity figure. Third, the LC-MS mass matches the expected molecular weight, here 1419.56 g/mol. Anything that does not line up, send us the lot code.
Add bacteriostatic water slowly down the inner wall of the vial and swirl — never shake. Once in solution, refrigerate at 2–8 °C, protect from light and use within 30 days. Unopened vials keep at ambient temperature short term, or at −20 °C beyond three months.
Orders placed before 2 PM Pacific dispatch the same working day. Domestic delivery is two days, with tracking sent on dispatch. Shipping is free on orders over $200. International orders go out with a commercial invoice; transit is typically five to nine days.
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