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DSIP 5 mg supplied as a lyophilised vial. Tested at 99.925% purity by an independent laboratory. Certificate published under lot #58471.
98+
Every lot has a certificate from an independent laboratory, typically for HPLC purity and identity.
1–3
Orders are usually prepared for shipment within 1–3 business days, then tracked end to end.
COA
Read the latest certificate for the compound before you place the order, not after.
Certificate of analysis
The certificate of analysis an independent laboratory issued for the lot listed here: typically purity by HPLC and identity, and endotoxins where the laboratory tested them.
Lyophilised powder is stable at ambient temperature in transit. On arrival, keep sealed vials refrigerated at 2–8 °C, dry and dark. For storage beyond three months, keep at −20 °C.
Follow your laboratory's own protocol.
Refrigerate at 2–8 °C and protect from light. Use within 30 days. Discard if the solution becomes cloudy or discoloured.
For laboratory research use only. Not for human or veterinary consumption. Not a drug or dietary supplement.
Research record
Delta sleep-inducing peptide (DSIP) is a nonapeptide, Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, isolated in 1977 from the cerebral venous blood of rabbits during electrically induced sleep, and named for the slow-wave (delta) EEG activity it produced when infused into the brain.
01
Infused into the cerebral ventricles of rabbits under double-blind conditions, the synthetic nonapeptide raised delta EEG activity by a mean 35 per cent in the neocortex and limbic cortex, while five possible metabolic fragments, two analogues and a related tripeptide did not. Only the alpha-aspartyl form was highly active; its beta-aspartyl isomer was not.
02
Two double-blind studies examined the peptide in chronic insomnia. One found more total and stage 2 sleep but differences from placebo that already existed at baseline, and judged the improvement of little clinical significance; the other found higher sleep efficiency and shorter sleep latency, effects its authors called weak and partly due to a change in the placebo group.
03
In Cushing syndrome delta sleep and morning plasma DSIP-like immunoreactivity were both reduced, but the two correlated negatively, which the authors read as against a causal link; plasma levels did not mark disease in sleep apnoea. In steroid-primed ovariectomised rats the peptide stimulated LH release without acting on the pituitary directly.
| Research area | Assay |
|---|---|
| Sleep EEG | Delta and spindle activity after central infusion in rabbits |
| Neuroendocrine readouts | LH release in steroid-primed ovariectomised rats |
| Stroke models | Motor recovery after focal cerebral ischaemia in rats |
| Immunoassay | DSIP-like immunoreactivity in plasma |
Nearly fifty years after its isolation the human evidence is thin and inconsistent: the two controlled insomnia studies found small or doubtful effects, and plasma measurements have not followed sleep the way the name suggests. The compound holds no FDA approval.
Regulatory status as of October 2026.
2D structure · PubChem CID 68816
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Check three things in order. First, the lot code on the certificate matches the lot listed on the product page and in your order. Second, where the report gives an HPLC purity, its chromatogram shows a single dominant peak at the stated figure; a blend's report shows a peak for each compound. Third, where the lab ran mass spectrometry, the measured mass matches the expected molecular weight of the compound. Anything that does not line up, send us the lot code.
Unopened vials keep at ambient temperature short term, as in transit; on arrival, refrigerate them at 2–8 °C, and keep them at −20 °C beyond three months. Reconstitute following your laboratory's own protocol; once in solution, refrigerate at 2–8 °C, protect from light and use within 30 days.
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