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Peptide Blends Research Use Only · Not for Human or Veterinary Consumption

Cagrilintide / Semaglutide (GLP-1) 5/5 mg

Cagrilintide / Semaglutide (GLP-1) 5/5 mg supplied as a lyophilised vial. Certificate published under lot #68675.

Current lot
#68675 COA →
$144.99 $99.99 per vial, 5/5 mg

Quantity — volume pricing

30 ml +$14.99
In stock Lot #68675 View COA → $50 minimum order

At a glance

1–3

Business days to dispatch

Orders are usually prepared for shipment within 1–3 business days, then tracked end to end.

COA

Published before purchase

Read the latest certificate for the compound before you place the order, not after.

Certificate of analysis

The laboratory's report for the current lot

The certificate of analysis an independent laboratory issued for the lot listed here: typically purity by HPLC and identity, and endotoxins where the laboratory tested them.

Lot #68675
Identity Heavy metals only · As, Cd, Pb not detected
Laboratory Janoshik
Tested June 23, 2025

Specification

Physical form
Lyophilised powder
Net quantity
5/5 mg per vial
Current lot
#68675
Tested by
Janoshik
SKU
PFL-CAGRILINTIDE-SEMAGLUTIDE-5-5-MG

Storage & reconstitution

Before opening

Lyophilised powder is stable at ambient temperature in transit. On arrival, keep sealed vials refrigerated at 2–8 °C, dry and dark. For storage beyond three months, keep at −20 °C.

Reconstitution

Follow your laboratory's own protocol.

After reconstitution

Refrigerate at 2–8 °C and protect from light. Use within 30 days. Discard if the solution becomes cloudy or discoloured.

For laboratory research use only. Not for human or veterinary consumption. Not a drug or dietary supplement.

Research record

Three characterised lines of work

A two-component research vial: cagrilintide, a long-acting amylin analogue, and semaglutide, a long-acting GLP-1 analogue, 5 mg each in one lyophilised powder. The same pairing has been studied in clinical trials as two separately formulated peptides.

01

Cagrilintide component

A lipidated, long-acting analogue of amylin, developed to overcome the hormone's strong tendency to form amyloid fibrils and the short half-life of the earlier analogue pramlintide. Reviews describe amylin's satiating effect as acting on both homeostatic and hedonic regions of the brain.

02

Semaglutide component

A GLP-1 analogue with two amino-acid substitutions and a fatty-acid side chain that binds serum albumin, selected for prolonged exposure; in mini-pigs its plasma half-life after intravenous dosing was 46 hours.

03

The pair

Unlike most blends, this pairing has its own trial record: a phase 1b trial co-escalating the two components, a phase 2 trial in type 2 diabetes comparing the combination with each component alone, and phase 3 trials in adults with overweight or obesity, with and without type 2 diabetes, reported in 2025. In the phase 2 trial the combination reduced body weight more than either component, while its effect on glycated haemoglobin was greater than cagrilintide's but not significantly greater than semaglutide's.

Published research areas

Research area Assay
Amylin receptor pharmacology Activity at amylin 1, amylin 3 and calcitonin receptors
Peptide stability Fibrillation propensity of amylin analogues
GLP-1 receptor pharmacology Receptor potency and albumin binding of acylated analogues

The trials above tested the two peptides as separately formulated components; this vial holds both as one lyophilised mixture, and no study of such a pre-mixed powder was found. Semaglutide is the active ingredient of approved medicines; cagrilintide on its own holds no FDA approval, and an application to approve the two as a fixed-dose combination was filed with the FDA in December 2025.

Regulatory status as of October 2026.

References

  1. 1 Kruse T et al. (2021) Development of cagrilintide, a long-acting amylin analogue. J Med Chem. 10.1021/acs.jmedchem.1c00565
  2. 2 D'Ascanio AM, Mullally JA, Frishman WH (2024) Cagrilintide: a long-acting amylin analog for the treatment of obesity. Cardiol Rev. 10.1097/CRD.0000000000000513
  3. 3 Lau J et al. (2015) Discovery of the once-weekly glucagon-like peptide-1 (GLP-1) analogue semaglutide. J Med Chem. 10.1021/acs.jmedchem.5b00726
  4. 4 Enebo LB et al. (2021) Safety, tolerability, pharmacokinetics, and pharmacodynamics of concomitant administration of multiple doses of cagrilintide with semaglutide 2.4 mg for weight management: a phase 1b trial. Lancet. 10.1016/S0140-6736(21)00845-X
  5. 5 Frias JP et al. (2023) Efficacy and safety of co-administered once-weekly cagrilintide 2.4 mg with once-weekly semaglutide 2.4 mg in type 2 diabetes: a phase 2 trial. Lancet. 10.1016/S0140-6736(23)01163-7
  6. 6 Garvey WT et al. (2025) Coadministered cagrilintide and semaglutide in adults with overweight or obesity. N Engl J Med. 10.1056/NEJMoa2502081
  7. 7 Davies MJ et al. (2025) Cagrilintide-semaglutide in adults with overweight or obesity and type 2 diabetes. N Engl J Med. 10.1056/NEJMoa2502082

Common questions

Ordering, handling and compliance. Anything not covered here, write to support@pureforgelabs.com.

What does research use only actually mean?

Every compound we sell is supplied for laboratory research and development only. It is not a drug, not a supplement, and not intended to diagnose, treat, cure or prevent any condition in humans or animals. Buying from this site means you are acquiring it for in vitro or other controlled research work.

Who is allowed to order?

Purchasers must be 21 or older and are responsible for compliance with the law where they take delivery. We ship to research institutions, laboratories and qualified individual researchers in the United States only. We do not ship to jurisdictions where these compounds are restricted.

How do I read the certificate of analysis?

Check three things in order. First, the lot code on the certificate matches the lot listed on the product page and in your order. Second, where the report gives an HPLC purity, its chromatogram shows a single dominant peak at the stated figure; a blend's report shows a peak for each compound. Third, where the lab ran mass spectrometry, the measured mass matches the expected molecular weight of the compound. Anything that does not line up, send us the lot code.

How should it be stored?

Unopened vials keep at ambient temperature short term, as in transit; on arrival, refrigerate them at 2–8 °C, and keep them at −20 °C beyond three months. Reconstitute following your laboratory's own protocol; once in solution, refrigerate at 2–8 °C, protect from light and use within 30 days.

When does it ship and how?

Orders are normally prepared for shipment within 1–3 business days and ship to street addresses in the United States only — not to P.O. boxes or APO/FPO/DPO military addresses. Shipping is free on orders over $150 and a flat $14.95 below that.

What payment methods do you take?

We take credit and debit cards, paid securely at checkout. Bank transfers and purchase orders are not available at the moment.

What if a vial arrives damaged?

Keep the vial and all the packaging, photograph the damage and email support@pureforgelabs.com within 48 hours of delivery with your order number. Once the claim is verified, we replace the vial or refund what you paid for it. Please do not send anything back unless we ask you to — apart from damaged or incorrect items, all sales are final.

Do you handle bulk and wholesale orders?

Yes, by quote. The volume tiers on the product pages go up to five vials; for larger research quantities email support@pureforgelabs.com with the compounds and amounts, and we will quote per gram.

FOR RESEARCH USE ONLY. NOT FOR HUMAN OR VETERINARY CONSUMPTION. This product is intended solely for legitimate laboratory, analytical, and scientific research. It is not intended to diagnose, treat, cure, mitigate, or prevent any disease and is not intended for human or veterinary administration or consumption. All products are intended for research and identification purposes only. These products are not intended for human dosing, injection, or ingestion.

$99.99
Cagrilintide / Semaglutide (GLP-1) 5/5 mg · 5/5 mg · 1 vial

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