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Retatrutide (GLP-3) 15 mg supplied as a lyophilised vial. Tested at 99.9% purity by an independent laboratory. Certificate published under lot COA5496.
98+
Every lot has a certificate from an independent laboratory, typically for HPLC purity and identity.
1–3
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COA
Read the latest certificate for the compound before you place the order, not after.
Certificate of analysis
The certificate of analysis an independent laboratory issued for the lot listed here: typically purity by HPLC and identity, and endotoxins where the laboratory tested them.
Lyophilised powder is stable at ambient temperature in transit. On arrival, keep sealed vials refrigerated at 2–8 °C, dry and dark. For storage beyond three months, keep at −20 °C.
Follow your laboratory's own protocol.
Refrigerate at 2–8 °C and protect from light. Use within 30 days. Discard if the solution becomes cloudy or discoloured.
For laboratory research use only. Not for human or veterinary consumption. Not a drug or dietary supplement.
Research record
Retatrutide (LY3437943), here in 15 mg vials, is a single synthetic peptide that acts as an agonist at three receptors: those for glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1) and glucagon. It was developed to test whether glucagon-receptor activity, reported to raise energy expenditure, adds to the reduction in food intake associated with the two incretin receptors.
01
In cell-based assays the peptide showed balanced activity at the glucagon and GLP-1 receptors and greater activity at the GIP receptor. In obese mice it lowered body weight and improved glycaemic control, and the authors attribute the added weight loss to glucagon-receptor-mediated increases in energy expenditure on top of the reduction in calorie intake driven through the GIP and GLP-1 receptors.
02
A first pharmacokinetic study in people was followed by placebo-controlled trials: phase 2 in adults with obesity and in adults with type 2 diabetes, and phase 3 in type 2 diabetes, reporting reductions in body weight and, in type 2 diabetes, in glycated haemoglobin. In the phase 3 trial the most frequent adverse events were gastrointestinal, generally mild to moderate, and subsided over time.
03
In a substudy of the phase 2 obesity trial, participants with metabolic dysfunction-associated steatotic liver disease had liver fat measured at 24 weeks: reductions from baseline were dose-dependent against no change with placebo, and were related to changes in body weight, abdominal fat and measures of insulin sensitivity and lipid metabolism.
| Research area | Assay |
|---|---|
| Receptor pharmacology | cAMP signalling at the GIP, GLP-1 and glucagon receptors in cell lines |
| Energy balance | Food intake and energy expenditure in diet-induced obese mice |
| Glycaemic control | Glucose tolerance in obese mice |
Retatrutide holds no FDA approval: in 2026 its phase 3 programme — obesity, obstructive sleep apnoea, knee osteoarthritis and type 2 diabetes — was still enrolling or reporting. Reviews of the class describe its adverse events as primarily gastrointestinal, and count a substantial loss of lean mass alongside fat among the open questions for incretin-based agents, retatrutide included.
Regulatory status as of October 2026.
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Check three things in order. First, the lot code on the certificate matches the lot listed on the product page and in your order. Second, where the report gives an HPLC purity, its chromatogram shows a single dominant peak at the stated figure; a blend's report shows a peak for each compound. Third, where the lab ran mass spectrometry, the measured mass matches the expected molecular weight of the compound. Anything that does not line up, send us the lot code.
Unopened vials keep at ambient temperature short term, as in transit; on arrival, refrigerate them at 2–8 °C, and keep them at −20 °C beyond three months. Reconstitute following your laboratory's own protocol; once in solution, refrigerate at 2–8 °C, protect from light and use within 30 days.
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